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Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4)

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Epidemiology Occurs in 30–80% of individuals with hypothyroidism [12] Most common in patients with Hashimoto thyroiditis [13] Clinical features [13] Slowly progressive proximal muscle weakness Myalgia, muscle cramps, increased muscle tone Myoedema (highly specific sign): localized painless muscle contraction induced by light muscle percussion or pressure that manifests with palpable muscle swelling